The four players who will compete in the Unibet Premier League Play-Offs will be confirmed on Night 16 in Milton Keynes on Thursday, while the league phase winner will also be crowned in front of a sell-out Marshall Arena.
Wednesday's Night 15 saw Nathan Aspinall and Jose de Sousa book their places in the Play-Offs, joining Michael van Gerwen booked his top four spot on Night 14.
Dimitri Van den Bergh and Jonny Clayton will go head-to-head in a sudden-death match for the final Play-Off place, though Clayton would qualify should the contest end a draw.
Van Gerwen needs just a point against already-eliminated Peter Wright to secure top spot. Aspinall must defeat De Sousa to keep alive his hopes of finishing first.
James Wade and Gary Anderson cannot qualify for the Play-Offs.
2021 Unibet Premier League
Night 16 - Thursday May 27
Gary Anderson v James Wade
Nathan Aspinall v Jose de Sousa
Peter Wright v Michael van Gerwen
Dimitri Van den Bergh v Jonny Clayton
Play-Offs - Friday May 28