Peter Wright and Michael van Gerwen will face Fallon Sherrock and Lisa Ashton respectively on the opening day of the Cazoo Grand Slam of Darts, with the group stage draw for the Wolverhampton event having been made.
The 32-player tournament will be staged at the Aldersley Leisure Village from November 13-21, with the players competing for the Eric Bristow Trophy and a £125,000 top prize.
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The draw has pitted reigning champion Jose de Sousa against UK Open runner-up Luke Humphries, World Cup finalist Mensur Suljovic and Canada's Matt Campbell in Group F.
The two PDC Women's Series qualifiers, Sherrock and Ashton, have been drawn alongside two of the sport's biggest names for the round-robin phase.
Sherrock will make her Grand Slam debut against World Matchplay champion Wright on Saturday November 13, with Germany's Gabriel Clemens and Belgium's Mike De Decker also drawn in Group E.
Ashton, meanwhile, faces three-time Grand Slam champion Van Gerwen in her opening two in Group G, which also features Joe Cullen and World Cup winner John Henderson.
World Champion Gerwyn Price has been drawn alongside Krzysztof Ratajski, Martin Schindler and Nathan Rafferty in Group A.
Jonny Clayton, who has won the Masters, Premier League, World Grand Prix and World Series of Darts Finals in 2021, tops Group B alongside Mervyn King, Bradley Brooks and the European Development Tour champion, who will be confirmed on Sunday.
UK Open champion James Wade and European Championship winner Rob Cross are joined by Croatia's Boris Krcmar and Wales' Jim Williams in Group C, with Group D featuring Dimitri Van den Bergh, Stephen Bunting, Ryan Joyce and Rowby-John Rodriguez.
2012 Grand Slam of Darts champion Raymond van Barneveld secured his return to the event in Friday's Tour Card Holder Qualifier, and he joined sixth seed Gary Anderson, Michael Smith and Joe Davis in Group H.
Watch the Cazoo Grand Slam of Darts draw below
2021 Cazoo Grand Slam of Darts Draw
Group A
(1) Gerwyn Price
Krzysztof Ratajski
Martin Schindler
Nathan Rafferty
Group B
(8) Jonny Clayton
Mervyn King
Bradley Brooks
European Development Tour Champion
Group C
(4) James Wade
Rob Cross
Boris Krcmar
Jim Williams
Group D
(5) Dimitri Van den Bergh
Stephen Bunting
Ryan Joyce
Rowby-John Rodriguez
Group E
(2) Peter Wright
Gabriel Clemens
Mike De Decker
Fallon Sherrock
Group F
(7) Jose de Sousa
Luke Humphries
Mensur Suljovic
Matt Campbell
Group G
(3) Michael van Gerwen
Joe Cullen
John Henderson
Lisa Ashton
Group H
(6) Gary Anderson
Michael Smith
Raymond van Barneveld
Joe Davis