Rob Cross will begin the defence of his Cazoo European Championship title against 2018 winner James Wade on the opening night of this year's showpiece, with the schedule of play confirmed for the four-day event in Dortmund from October 27-30.
The 32-player field was finalised following last weekend's Gibraltar Darts Trophy, with the top 32 players on the European Tour Order of Merit following the year's 13 European Tour events securing qualification.
Fourth seed Cross will kick off his bid for a third European Championship crown with a blockbuster first round tie against Wade at the Westfalenhalle on Thursday October 27, in a battle of the former champions.
The opening night will also see a further seven first round clashes take place, as top seed Luke Humphries - a winner of four European Tour titles in 2022 - opens his campaign against Poland's number one Krzysztof Ratajski.
Fifth seed Damon Heta - who celebrated his maiden European Tour title in Gibraltar last weekend - faces Vincent van der Voort in Thursday's finale, with Michael Smith up against Czech ace Karel Sedlacek.
World Grand Prix runner-up Nathan Aspinall takes on emerging star Josh Rock in another tasty tie, while UK Open champion Danny Noppert plays Andrew Gilding - one of six debutants in this year's field.
Ryan Searle takes on another newcomer in Martin Lukeman, while Dirk van Duijvenbode opens this year's tournament against Latvia's Madars Razma.
The first round draws to a close on Friday October 28, as four-time champion Michael van Gerwen faces Chris Dobey, and World Champion Peter Wright takes on debutant Ryan Meikle.
Third seed Wright will play Gerwyn Price in round two if the Welshman overcomes Rowby-John Rodriguez in his opener, with Price's compatriot Jonny Clayton pitted against Germany's number one Gabriel Clemens.
Clemens' World Cup partner Martin Schindler plays Jose De Sousa, while two-time semi-finalist Joe Cullen meets Ross Smith for a place in the last 16.
Elsewhere, TV title winners Dimitri Van den Bergh and Daryl Gurney collide, as St Helens stars Dave Chisnall and Stephen Bunting do battle in Friday's opening tie.
Following the conclusion of the first round, the last 16 will take place across two sessions on Saturday October 29, before the tournament concludes with the quarter-finals, semi-finals and final in a bumper double-session on Sunday October 30.
The tournament will be broadcast live on ITV4 in the UK, through the PDC's worldwide broadcast partners including DAZN and Viaplay, and on PDCTV (excluding UK and Netherlands based subscribers).
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2022 Cazoo European Championship
Schedule of Play
Thursday October 27 (1845 local time, 1745 BST)
8x First Round
Dirk van Duijvenbode v Madars Razma
Ryan Searle v Martin Lukeman
Danny Noppert v Andrew Gilding
Rob Cross v James Wade
Luke Humphries v Krzysztof Ratajski
Nathan Aspinall v Josh Rock
Michael Smith v Karel Sedlacek
Damon Heta v Vincent van der Voort
Friday October 28 (1845 local time, 1745 BST)
8x First Round
Dave Chisnall v Stephen Bunting
Dimitri Van den Bergh v Daryl Gurney
Joe Cullen v Ross Smith
Jose de Sousa v Martin Schindler
Peter Wright v Ryan Meikle
Gerwyn Price v Rowby-John Rodriguez
Michael van Gerwen v Chris Dobey
Jonny Clayton v Gabriel Clemens
Saturday October 29
Afternoon Session (1345 local time, 1245 BST)
4x Second Round
Evening Session (2000 local time, 1900 BST)
4x Second Round
Sunday October 30
Afternoon Session (1300 local time, 1200 GMT)
Evening Session (1900 local time, 1800 GMT)
Semi-Finals & Final
(1) Luke Humphries v (32) Krzysztof Ratajski
(16) Ryan Searle v (17) Martin Lukeman
(8) Michael Smith v (25) Karel Sedlacek
(9) Nathan Aspinall v (24) Josh Rock
(4) Rob Cross v (29) James Wade
(13) Dirk van Duijvenbode v (20) Madars Razma
(5) Damon Heta v (28) Vincent van der Voort
(12) Danny Noppert v (21) Andrew Gilding
(2) Michael van Gerwen v (31) Chris Dobey
(15) Jose de Sousa v (18) Martin Schindler
(7) Dave Chisnall v (26) Stephen Bunting
(10) Jonny Clayton v (23) Gabriel Clemens
(3) Peter Wright v (30) Ryan Meikle
(14) Gerwyn Price v (19) Rowby-John Rodriguez
(6) Joe Cullen v (27) Ross Smith
(11) Dimitri Van den Bergh v (22) Daryl Gurney